The Promise of NAD+ Therapy: Understanding the Benefits and Science

Health
Written By Jennifer Glasshagel

NAD+ (nicotinamide adenine dinucleotide) has emerged as one of the most talked-about molecules in longevity and wellness circles. This coenzyme, found in every cell of your body, plays a crucial role in energy production and cellular health. As we age, our NAD+ levels naturally decline, which has led researchers and clinicians to explore NAD+ supplementation and therapy as a potential intervention for age-related decline and various health conditions.

What Is NAD+?

NAD+ is a coenzyme that exists in two forms in your cells: NAD+ (oxidized) and NADH (reduced). It's essential for converting the food you eat into usable energy and supports hundreds of metabolic processes. Beyond energy production, NAD+ activates proteins called sirtuins, which are involved in DNA repair, inflammation regulation, and cellular stress resistance.

The Decline of NAD+ With Age

Research has consistently shown that NAD+ levels decrease as we age. By middle age, your NAD+ levels may be half of what they were in youth. This decline has been linked to various age-related changes and conditions, making NAD+ restoration an attractive therapeutic target.

Potential Benefits of NAD+ Therapy

Enhanced Energy and Reduced Fatigue

Many people report increased energy levels and reduced fatigue after NAD+ therapy. Since NAD+ is fundamental to mitochondrial function—the powerhouses of your cells—boosting levels may help optimize cellular energy production. This can translate to improved physical stamina and mental clarity.

Cognitive Function Support

NAD+ plays a protective role in brain health. Some studies suggest that maintaining adequate NAD+ levels may support cognitive function, potentially helping with focus, memory, and overall mental performance. The neuroprotective properties of NAD+ are being investigated for conditions like Alzheimer's disease and other neurodegenerative disorders.

Metabolic Health

NAD+ is involved in regulating metabolism and maintaining healthy blood sugar levels. Research has explored NAD+ boosters for their potential to improve insulin sensitivity and support metabolic health, which could have implications for managing conditions like diabetes and metabolic syndrome.

DNA Repair and Cellular Health

One of NAD+'s most important roles is supporting DNA repair mechanisms. As we age and accumulate DNA damage from various stressors, adequate NAD+ levels become crucial for maintaining cellular integrity and function. This is partly why NAD+ is being studied in the context of healthy aging.

Improved Sleep Quality

NAD+ plays a role in regulating your body's circadian rhythms—the internal clock that governs sleep-wake cycles. By supporting cellular energy metabolism and helping maintain proper circadian function, NAD+ therapy may contribute to better sleep quality and more consistent sleep patterns. Some users report falling asleep more easily and experiencing more restorative rest, though individual experiences vary.

Enhanced Skin Health

The skin is one of the most visible indicators of aging, and NAD+ may offer benefits for skin health and appearance. NAD+ supports cellular repair processes that are crucial for maintaining healthy skin cells. It may help protect against oxidative stress and UV damage while supporting collagen production and skin elasticity. Some research suggests that boosting NAD+ levels could help reduce visible signs of aging in the skin, including fine lines and wrinkles, though more clinical studies are needed to confirm these cosmetic benefits.

Potential Anti-Aging Effects

While the term "anti-aging" should be taken with caution, NAD+ therapy has generated interest in longevity research. By supporting sirtuins and other longevity-related pathways, NAD+ may help maintain cellular health and function as we age, though more research is needed to fully understand these effects in humans.

Methods of NAD+ Therapy

At Restoration Health and Wellness, we offer NAD+ therapy through IV infusions and subcutaneous injections—delivery methods we trust to provide you with optimal absorption and results.

- IV infusions -

Delivery & Effectiveness:

  • Fastest absorption method - goes directly into bloodstream

  • 100% bioavailability (bypasses digestive system)

  • Immediate peak effect, but shorter duration

Dosing & Administration:

  • 100-1,000 mg per session

  • 2-4 hour infusion time

  • Requires clinical setting with medical supervision

  • Needs IV/venous access

Cost & Convenience:

  • More expensive due to clinical setting and supervision

  • Time-intensive process

Side Effects:

  • Potential for nausea, flushing, chest pressure

  • Side effects depend on infusion speed

Best For:

  • Patients needing immediate, powerful effects

  • Severe fatigue or energy depletion

- Subcutaneous injections -

Delivery & Effectiveness:

  • Slow, gradual absorption under the skin

  • Peak levels reached in 1-2 hours

  • 70-80% bioavailability (lower than IV)

  • Sustained effect lasting 8-12 hours with steady NAD levels

Dosing & Administration:

  • Lower doses: 50-200 mg per injection

  • Frequency: 1-3 times per week

  • Can be self-administered at home after training

  • More convenient and flexible

Cost & Convenience:

  • Lower cost per session than IV

  • Less invasive

  • No clinical setting required

Side Effects:

  • Localized reactions only

  • Mild burning, discomfort, or bruising at injection site

  • Generally better tolerated

Best For:

  • Maintenance therapy

  • Those preferring gradual, consistent NAD boosting

  • Patients wanting a less invasive, more convenient option

  • Long-term wellness support

Important Considerations

Research is ongoing: Many benefits are supported by preclinical studies, and more human clinical trials are needed

Individual variation: People may respond differently to NAD+ therapy

Quality matters: The source and quality of NAD+ products vary significantly

Medical supervision: Consult healthcare providers before starting NAD+ therapy, especially if you have underlying health conditions

Potential But Rare Side Effects: nausea, headaches, brain fog, cramping during therapy, fatigue, redness or swelling at site, diarrhea, bruising at injection site, and abdominal pain

The Bottom Line

NAD+ therapy represents an exciting frontier in cellular health and longevity medicine. While the science supporting its various benefits continues to evolve, the fundamental importance of NAD+ in cellular function is well-established. As with any health intervention, it's essential to stay informed, work with qualified healthcare providers, and maintain realistic expectations while the research continues to unfold.

Sources and Further Reading

For more information on NAD+ and its therapeutic potential, consider exploring these resources:

Disclaimer: This blog is for informational purposes only and should not replace professional medical advice. Always consult with a qualified healthcare provider before starting any new therapy or supplement regimen.

Jennifer Glasshagel
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